ScienceDaily: Biotechnology News

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• Molecular mechanism links temperature with sex determination in some fish species
• New findings about the prion protein and its interaction with the immune system
• DNA mismatch repair happens only during a brief window of opportunity
• Plasma treatment zaps viruses before they can attack cells
• The mystery behind the building of muscle: Jamb and Jamc are essential proteins for the fusion of muscle cells

Molecular mechanism links temperature with sex determination in some fish species Posted: 29 Dec 2011 05:30 PM PST Researchers have found the epigenetic mechanism that links temperature and gonadal sex in fish. High temperature increases DNA methylation of the gonadal aromatase promoter in females.

New findings about the prion protein and its interaction with the immune system Posted: 29 Dec 2011 06:16 AM PST Scrapie is a neurodegenerative disease which can function as a model for other diseases caused by an accumulation of proteins resulting in tissue malformations (proteinpathies), such as Alzheimer's and Parkinson's disease. Many questions regarding these diseases still remain unanswered. A new study has uncovered a number of factors relating to the uptake of the prion protein (PrPSc) associated with the development of this disease and how this protein interacts with the immune cells in the intestines.

DNA mismatch repair happens only during a brief window of opportunity Posted: 22 Dec 2011 11:24 AM PST In eukaryotes-the group of organisms that include humans –- a key to survival is the ability of certain proteins to quickly and accurately repair genetic errors that occur when DNA is replicated to make new cells. Researchers have solved part of the mystery of how these proteins do their job, a process called DNA mismatch repair.

Plasma treatment zaps viruses before they can attack cells Posted: 16 Dec 2011 08:28 AM PST Researchers have tested a pre-emptive anti-viral treatment on a common virus known to cause respiratory infections.

The mystery behind the building of muscle: Jamb and Jamc are essential proteins for the fusion of muscle cells Posted: 13 Dec 2011 03:51 PM PST Cell fusion, the union of precursor cells to form one large cell containing many nuclei, is crucial to the development and maintenance of several tissues; for example, the placenta, bone-reshaping osteoclasts and skeletal muscle. Finding out which genes are essential for this process has been of great interest for decades, but surprisingly little is known about the cell and molecular biology of the process in vertebrates. This research describes two vertebrate-specific cell surface receptors that are essential for fusion between muscle precursors in zebrafish: Jamb and Jamc. Loss-of-function of either of these proteins prevents fusion, resulting in an overabundance of muscle fibers with single nuclei.

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Alexion Scoops Up Enobia for Around $1B - Dec. 29, 2011

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Thursday, December 29, 2011  |   |   |   |  Online Auction January 11 at 9 AM ET Featuring lab equipment from Elan and other leading global firms! Register and bid online. •   Alexion Pharmaceuticals Inc. (ALXN) Scoops Up Enobia Pharma for Around $1 Billion More... •   Opko Health, Inc. Completes Acquisition of FineTech Pharmaceutical, Ltd. More... More Mergers and Acquisitions News •  AstraZeneca PLC (AZN)'s Loughborough Workforce Find New Jobs More... More Job Industry News •   Biotech Startup, Daktari Diagnostics Raises $5 Million in Financing Round More... •   Santa Cruz Biopharm Firm Tosk Looks to Raise $5.1 Million More... More Startup News •   Excel Venture Eyes $150 Million Second Life Sciences Fund More... •   Marshall Edwards, Inc. (MSHL) Adds $2 Million in Private Placement More... More Finance News Quantifying the Value of Pipeline Pilot, the Accelrys Scientific Enterprise Platform This white paper outlines the methodology, sources of value, and quantifiable results from bringing products to market faster, avoiding unproductive experiments, saving developer time, and more. Request Now! •   Abbott Laboratories (ABT) to End Venture With Emergent BioSolutions (EBS) on Cancer Drug More... More Alliances News •   China Sky One Medical, Inc. Announces Resignation of its Chief Financial Officer More... More Personnel News •   AAIPharma Services Achieves Record Quarterly Results More... More Earnings Report News •   Illumina, Inc. (ILMN) Accuses Life Technologies (LIFE) of Infringing Patent More... More Legal News •   Alpha Group Holdings to Build $50 Million Plant More... More Construction News   Property Available 500 West Cartier Boulevard Laval, Quebec Canada • Over 900 linear feet of laboratory work stations with attendant built-in services distributed throughout chemistry and biology labs • Biological safety cabinets/fume hoods of assorted sizes, (including walk-ins) • 2 UPS systems More Real Estate Listings Hot Company SGS Life Science Services 201 Route 17 North Rutherford, New Jersey 07070 U.S.A. Phone: 201-508-3000 SGS Life Science Services is a leading contract service organization providing clinical research, analytical development, biologics characterization, and quality control testing. SGS serves various life science companies, including pharmaceutical, biopharmaceutical, biotechnology, and medical-device manufacturers. More Company Profiles Drug Delivery Partnerships is THE meeting place to discover innovative products, anticipate and take advantage of trends in the partnering landscape and implement best practices to ensure your company stays ahead of the curve. Drug Delivery Partnerships is hailed by all as the world's most authoritative conference on collaboration to drive progress in drug delivery. You will uncover NEW partners, NEW drug delivery technologies, and NEW formulation development strategies to accelerate drugs to market and lengthen lifecycles for long term profitability. For more information, please visit: http://www.iirusa.com/ddp/welcome.xml.   • Biotech Bay (Mountain View, California) Complete Genomics, Inc. Technical Marketing Manager Responsible for the creation of technical product marketing materials with an emphasis on data and data analysis that directly support sales and growth of the Complete Genomics business. • Genetown (Cambridge, Massachusetts) AVEO Pharmaceuticals, Inc. Associate Director, Marketing Responsible for developing and implementing the launch strategic and tactical plans for tivozanibs successful entry into the RCC market. The person will be responsible for conditioning the market, being part of establishing and leveraging key KOL relations and market education efforts. • BioCapital (Baltimore, Maryland) Astellas Pharma US Regional Sales Manager Responsible for the development of sales strategies and achievement of Primary Care sales objectives within a determined geography. This position is also responsible for the management and development of 8-12 Professional Representatives (PCPs), market activities, and company resources within a given district that are directed specifically at maximizing territory, district, area and national sales goals and market share objectives. • BioMidwest (McGaw Park, Illinois) Baxter International, Inc. Senior Manager, Marketing Responsible for developing and executing on strategies to drive demand for Home Dialysis Therapies through therapy marketing and therapy education. • Biotech Beach (San Diego, California) Sequenom Inc. Business Development Manager Will represent Sequenom products to targeted customers, whose patients may benefit from our superior science. The ideal candidate will plan, develop, and manage long-term relationships with physicians and clinical laboratories to attain or exceed sales targets. • Get Noticed! Add your resume to the BioSpace Career Center! • See more than 5,000 job postings in the BioSpace Career Center! BioSpace Life Science Career Fairs are the biotech industry's premier career events. Featuring well-respected employers from around the nation, our job fairs attract top candidates in the biotech, pharmaceutical, life science and medical device industries. With such a great number of recruiters and hiring managers from top biotech companies attending our career fairs, there are an abundance of opportunities available for job seekers. Many different disciplines within the industry are represented bringing a diversity of candidates to our job fairs. Companies seeking pharmaceutical sales representatives and marketing jobs regularly attend our job fairs. Engineering and technical jobs can be found, as well as regulatory jobs and positions in QA/QC. Individuals desiring a science job or a research job will find many opportunities at our job fairs. In addition, hiring managers seeking candidates for clinical research jobs also attend our events. More information about BioSpace's Career Fairs BioSpace White Paper Biotech Career Fairs For Job Seekers 101: Control Your Experience By June Salvati, BioSpace Director of Events and Corporate Services Post Your: News | Jobs | Company Profile | Event | Advertising / Sponsorship BioSpace, Inc. 6465 South Greenwood Plaza, Suite 400 Centennial, Colorado 80111 U.S.A. Phone: 877-277-7585 Fax: 800-595-2929 BioSpace, Inc. 90 New Montgomery Street, Suite 414 San Francisco, California 94105 U.S.A. Phone: 877-277-7585 Fax: 415-576-9217 Send questions and comments to the BioSpace News Beat Team. Editor & Publisher: Rosemary Do Editorial & Production Staff: Lana Ho, Maysa Darwish, Tammy Liu, Michelle Wong BioSpace.com - Life. Science. Community. • BioSpace is a registered trademark of BioSpace, Inc. • Please distribute this e-cast freely. • Credit any excerpts as follows: Copyright 2011 BioSpace http://www.biospace.com • While BioSpace and its agents used their best efforts in collecting and preparing the information published herein, we do not assume, and hereby disclaim, any liability for any loss or damage caused by errors or omissions, whether such errors or omissions resulted from negligence, accident or other causes. If someone forwarded this news to you and you'd like to receive your own copy FREE of charge, simply Subscribe here. Safely unsubscribe from Biospace.com e-mail at any time by managing your account here.

Roche's Avastin Disappoints Against Ovarian Cancer - Dec. 29, 2011

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Thursday, December 29, 2011  |   |   |   |  UC Berkeley Extension Clinical and Regulatory Sciences Get the specialized instruction you need to advance your career. UC Berkeley Extension offers targeted certificates and programs to provide essential skills to design and manage clinical trials, navigate compliance issues and ensure new products and processes adhere to U.S. and international regulatory specifications. Choose from programs in: • Clinical Research Conduct and Management (available online) • Quality and Compliance for Biotechnology • Regulatory Affairs Spring courses are open for enrollment. Learn more. •  Roche (RHHBY)'s Avastin Disappoints Against Ovarian Cancer More... More Phase III News More Phase II News More Phase I News More Pre-Clinical News More Post-Approval News •  Janssen Research & Development: Xarelto Submitted for Further US Marketing Authorization More... •  IGI Laboratories, Inc. Announces the Submission of Fifth ANDA More... •  Gentium S.p.A. Provides Update on MAA Process for Defibrotide in Europe More... More BLA/NDA/ANDA News More IND News More MAA News Quantifying the Value of Pipeline Pilot, the Accelrys Scientific Enterprise Platform This white paper outlines the methodology, sources of value, and quantifiable results from bringing products to market faster, avoiding unproductive experiments, saving developer time, and more. Request Now! •  Vitamins, Omega-3s May Keep Brain From Shrinking, Oregon Health & Science University (OHSU) Study More... •  Red Meat Lovers Have More Kidney Cancer, American Journal of Clinical Nutrition Reveals More... •  Get First Cat as Adult, Double Allergy Risk, University of Verona Study More... •  New Powerful Painkiller From Zogenix, Inc. Has Abuse Experts Worried More... •  Exercise Doesn't Prevent Pregnancy-Related Diabetes, Norwegian University of Science and Technology Study More... More General Clinical Research News SafeBridge Consultants, Inc. announces two Potent Compound Safety Training offerings (may be taken separately or consecutively) The SafeBridge original Potent Compound Safety "Boot Camp"® (Boot Camp I) is a comprehensive two-day course in pharmaceutical potent compound safety focused on training EH&S and related professionals in critical technical concepts and proactive safety programs in pharmaceutical industrial hygiene, occupational and environmental toxicology, analytical chemistry, and risk communication. The SafeBridge Advanced Concepts to Support Drug Development of Potent Compounds from R&D through Manufacturing (Boot Camp II) is a one-day advanced course focused on case studies and problem-solving to address potent compound safety issues in discovery, development, contract manufacturing and commercialization. COURSE SEATING IS LIMITED AND USUALLY SELLS OUT! San Diego, CA Boot Camp I May 15-16, 2012 Boot Camp II May 17, 2012 Contact Susan Custer: susan.custer@safebridge.com, or 650-961-4820 x 231 or www.safebridge.com. Biomarkers in Late Stage Clinical Trials • Quantify and analyze revenues of late stage biomarker technology and services in North America, Europe, Asia and the Rest of the World. • Identify the key market drivers and resistors of the biomarker market and evaluate the growth potential of emerging technologies • Assess biomarker activity at leading companies, including Abbott, AZ, BMS, Eli Lilly, GSK, Merck & Co, Novartis, Pfizer, Roche and Sanofi-Aventis. Click Here for More Information. • Biotech Bay (South San Francisco, CA) KAI Pharmaceuticals, Inc. Director/Senior Director Clinical Operations Lead clinical operations strategic planning activities and translate strategic decisions into actionable operational plans. Identify the resource needs for implementation of operational plans and develop a resource-tracking process. • Bio NC (Durham, North Carolina) PAREXEL International Medical Director, Clinical Trials, Internal Medicine, or Sub-Specialty Provide medical monitoring for assigned projects; function as medical representative on the project team; provide medical consultation as required or requested to client/sponsor or to other PAREXEL service groups; and assume the role of Senior Technical Lead in selected circumstances. • Genetown (Cambridge, Massachusetts) Vertex Clinical Data Management Lead Responsible for a variety of technical and leadership duties including accurate and consistent reporting and documentation within GIS, Application Development. The Lead ensures that projects are completed in a timely manner and meet the required objectives. • Biotech Beach (Los Angeles, California) CytRx Corporation Clinical Study Manager Assessing global vendor requirements and liaising with appropriate departments on vendor selection followed by continued global vendor management. Site startup and management activities, including budgeting and contract negotiations. • BioForest (Woodinville, Washington) Bio-Rad Laboratories, Inc. Clinical Diagnostics Group RA/QA/QC Supervisor II Supervise and coordinate quality control activities for the BioPlex 2200 QC team in the Woodinville facility including raw materials QC, coupled antigens or antibodies to magnetic particles, conjugated antibodies with fluorescent tags, and critical component manufacturing. • Get Noticed! Add your resume to the BioSpace Career Center! • See more than 5,000 job postings in the BioSpace Career Center! BioSpace Life Science Career Fairs are the biotech industry's premier career events. Featuring well-respected employers from around the nation, our job fairs attract top candidates in the biotech, pharmaceutical, life science and medical device industries. With such a great number of recruiters and hiring managers from top biotech companies attending our career fairs, there are an abundance of opportunities available for job seekers. Many different disciplines within the industry are represented bringing a diversity of candidates to our job fairs. Companies seeking pharmaceutical sales representatives and marketing jobs regularly attend our job fairs. Engineering and technical jobs can be found, as well as regulatory jobs and positions in QA/QC. Individuals desiring a science job or a research job will find many opportunities at our job fairs. In addition, hiring managers seeking candidates for clinical research jobs also attend our events. More information about BioSpace's Career Fairs BioSpace White Paper Biotech Career Fairs For Job Seekers 101: Control Your Experience By June Salvati, BioSpace Director of Events and Corporate Services •  Illumina, Inc. (ILMN) Accuses Life Technologies (LIFE) of Infringing Patent More... More Patent News Hot Company TransTech Pharma, Inc. 4170 Mendenhall Oaks Parkway High Point, North Carolina 27265 U.S.A. Phone: 336-841-0300 Fax: 336-841-0333 TransTech Pharma is a clinical-stage pharmaceutical company focused on the discovery and development of human therapeutics to fill unmet medical needs. Our mission is to utilize our innovative technology to rapidly translate the functional modulation of human proteins into safe and effective medicines. We have a pipeline of small molecule clinical and pre-clinical drug candidates for the treatment of a wide range of human diseases including central nervous system disorders, cardiovascular disorders, type I/II diabetes, obesity, and cancer. More Company Profiles Post Your: News | Jobs | Company Profile | Event | Advertising / Sponsorship ClinicaSpace 6465 South Greenwood Plaza, Suite 400 Centennial, Colorado 80111 U.S.A. Phone: 877-277-7585 Fax: 800-595-2929 ClinicaSpace 90 New Montgomery Street, Suite 414 San Francisco, California 94105 U.S.A. Phone: 877-277-7585 Fax: 415-576-9217 Send questions and comments to the ClinicaSpace News Beat Team. Editor & Publisher: Rosemary Do Editorial & Production Staff: Lana Ho, Maysa Darwish, Tammy Liu, Michelle Wong ClinicaSpace.com - Clinical Trials. Clinical Research. Community. • ClinicaSpace is a registered trademark of BioSpace, Inc. • Please distribute this e-cast freely. • Credit any excerpts as follows: Copyright 2011 ClinicaSpace http://www.clinicaspace.com • While BioSpace and its agents used their best efforts in collecting and preparing the information published herein, we do not assume, and hereby disclaim, any liability for any loss or damage caused by errors or omissions, whether such errors or omissions resulted from negligence, accident or other causes. If someone forwarded this news to you and you'd like to receive your own copy FREE of charge, simply Subscribe here. Safely unsubscribe from ClinicaSpace.com e-mail at any time by managing your account here.