Human Immune System in a Mouse. Cutting-edge models. Available now.

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Stay in touch    Cutting-edge models. Available now. Imagine how a mouse with an engrafted human immune system can take your drug discovery research to the next level. We utilize best-in-class immunodeficient mice, the NOD scid IL2 receptor gamma chain knockout (NSG, Stock No. 005557), which have been shown to support more robust human hematopoietic stem cell engraftment than any other strain (McDermott, et al, 2010. Blood 116:193-200). All major lineages of human hematopoietic cells are present in the mouse circulation 12 weeks post engraftment. Delayed type hypersensitivity (DTH) response can be induced in the engrafted mice indicating a functional human immune system. Research applications: Drug targets that lack human-mouse cross reactivity Infectious disease research on human specific pathogens Gene therapy utilizing hematopoietic stem cells Bone marrow toxicity/hematopoiesis Choose the option that best meets your needs. Study-ready cohorts of humanized mice are readily available for shipment to your institution or customized drug efficacy studies in humanized mice can be executed by our In Vivo Pharmacology group.

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