ScienceDaily: Biotechnology News |
- High-fat diet and lack of enzyme can lead to heart disease in mice
- Team finds stable RNA nano-scaffold within virus core
- Fish oil reduces effectiveness of chemotherapy
- Physicist detects movement of macromolecules engineered into our food
- 'Trojan Horse' particle sneaks chemotherapy in to kill ovarian cancer cells
| High-fat diet and lack of enzyme can lead to heart disease in mice Posted: 12 Sep 2011 11:35 AM PDT It's no secret that a high-fat diet isn't healthy. Now researchers have discovered a molecular clue as to precisely why that is. Mice lacking a gene-expression-controlling enzyme fed a high-fat diet experience rapid thickening of the heart muscle and heart failure. This link -- at least in mice -- has implications for people on so-called Western diets and combating heart disease. Modulating the enzyme's activity could be a new pharmaceutical target.  |
| Team finds stable RNA nano-scaffold within virus core Posted: 12 Sep 2011 11:34 AM PDT With the discovery of a RNA nano-scaffold that remains unusually stable in the body, researchers have overcome another barrier to the development of therapeutic RNA nanotechnology. The nanoparticle, constructed from a three-way junction (3WJ) motif of packaging RNA (pRNA) molecules, can serve as a platform for building larger, multifunctional nanoparticles -- which can then be injected into the body to deliver therapeutics to targeted cells.  |
| Fish oil reduces effectiveness of chemotherapy Posted: 12 Sep 2011 11:32 AM PDT The body produces a substance that renders cancer cells insensitive to treatment with widely used chemotherapies. The same substance is also contained in fish oil capsules that are taken by many cancer patients. The Dutch researchers who discovered the substance advise patients undergoing chemotherapy against the use of fish oil and similar products.  |
| Physicist detects movement of macromolecules engineered into our food Posted: 12 Sep 2011 07:21 AM PDT Toxin proteins are genetically engineered into our food because they kill insects by perforating body cell walls, and now researchers studying membrane proteins have detected the molecular mechanism involved.  |
| 'Trojan Horse' particle sneaks chemotherapy in to kill ovarian cancer cells Posted: 12 Sep 2011 07:21 AM PDT A common chemotherapy drug has been successfully delivered to cancer cells inside tiny microparticles using a method inspired by our knowledge of how the human immune system works. The drug, delivered in this way, reduced ovarian cancer tumors in an animal model by 65 times more than using the standard method. This approach is now being developed for clinical use.  |
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